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WHO diagnostic requirements for t MDS/AML collectively with FAB requirements for AML ended up applied. Chromosome preparation was carried out both immediately or immediately after non stimulated short term culture of bone marrow cells for 24–48 hrs, in accordance to the HG banding approach. The karyotypes ended up designated in accordance to the ISCN. Bone marrow biopsy with immunohistochemistry was carried out in all four clients.